The impact of axon wiring costs on small neuronal networks
نویسندگان
چکیده
Recent papers by D. Chklovskii and E.M. Izhikevich suggest that wiring costs may play a significant role in the physical layout and function of neuronal structures. About eighty years ago, in his paper on the relationship between diameter and branching angles in trees, C.D. Murray proposed the volume as the cost function which dictates growth. O. Shefi et al. grafted this idea into neuroscience as a possible optimisation mechanism. Our paper presents computational experiments on the impact of wiring cost functions proposed by D. Chklovskii and O. Shefi et al. when applied to interneuronal connections in small ML neuronal networks.
منابع مشابه
Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons.
The performance of the brain is constrained by wiring length and maintenance costs. The apparently inverse relationship between number of neurons in the various interneuron classes and the spatial extent of their axon trees suggests a mathematically definable organization, reminiscent of 'small-world' or scale-free networks observed in other complex systems. The wiring-economy-based classificat...
متن کاملStructural Properties of the Caenorhabditis elegans Neuronal Network
Despite recent interest in reconstructing neuronal networks, complete wiring diagrams on the level of individual synapses remain scarce and the insights into function they can provide remain unclear. Even for Caenorhabditis elegans, whose neuronal network is relatively small and stereotypical from animal to animal, published wiring diagrams are neither accurate nor complete and self-consistent....
متن کاملCommunication and wiring in the cortical connectome
In cerebral cortex, the huge mass of axonal wiring that carries information between near and distant neurons is thought to provide the neural substrate for cognitive and perceptual function. The goal of mapping the connectivity of cortical axons at different spatial scales, the cortical connectome, is to trace the paths of information flow in cerebral cortex. To appreciate the relationship betw...
متن کاملRESEARCH REPORT 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-Osulfotransferases HS6ST1 and HS6ST2 are ...
متن کاملDevelopmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion, and neurite outgrowth during development. In the mature nervous system, Nogo-A stabilizes neuronal wiring to inhibit neuronal plasticity and regeneration after injury. Here, we show that RET-1, the sole Nogo-A homolog in Caenorhabditis elegans, is required to control developmental wiring of a specific sub...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008